Corpus ID: 31020671

The effect of Carica papaya L. leaves extract capsules on platelets count and hematocrit level in dengue fever patient

@article{Yunita2012TheEO,
  title={The effect of Carica papaya L. leaves extract capsules on platelets count and hematocrit level in dengue fever patient},
  author={Fenny Yunita and Endang Sri Hanani and Jusuf Kristianto},
  journal={International Journal of Medicinal and Aromatic Plants},
  year={2012},
  volume={2},
  pages={573-578}
}
Indonesia is one of the countries with the highest cases of dengue fever in South East Asia. [...] Key Method The design of this study was randomized clinical trial with a sample size of 80 subjects. These subjects were ra n- domized into two groups of 40, including the control and intervention gro up (received two CPC three times daily). The results showed that CPC had significant increased the platelet count ( p<0.05), maintained stability of hemat ocrit in the normal level, shorten hospitalization ( p<0.05…Expand
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56 Citations
Background Citations
24
Methods Citations
1
Results Citations
5

56 Citations

Citation Type

Citation Type

The effect of Carica papaya leaves extract capsules on platelets count and hematocrit levels in acute febrile illness with thrombocytopenia patient
TLDR
Carica papaya leaf extract could be used as an additional or as a complementary drug in acute febrile illness patients with thrombocytopenia; it accelerates the increase in the platelet count and shorten the hospitalization thereby reducing the cost of hospitalization significantly. Expand
Effect of Carica papaya leaf formulation on Hematology and Serology of normal rat
TLDR
From the experimentation it can be concluded that C. papaya leaf extract is associated with rapid increase of platelet count, and the need for isolation and identification of the C. Papaya substances responsible for the release and/or production of thrombocytes. Expand
Therapeutic benefits of carica papaya leaf extracts in dengue fever patients
Carica Papaya (C. papaya) is commonly called as paw-paw and it belongs to the family Caricaceae. It have been successfully employed as a folk medicine for many years for the treatment of dengue… Expand
Effect of Papaya Leaves Extract on Platelets Count and Hemoglobin Levels of Dengue Patients
TLDR
The results indicated that the mean platelets count of the control group was 114200 + 72568.44 /µL and of experimental groups was 70222 + 67304 on the day of admission, while the mean hemoglobin levels of both the control and experimental groups were 11.48 mg/ and 11.58 gm/dl respectively. Expand
Research article THERAPEUTIC POTENTIAL OF CARICA PAPAYA L. LEAF EXTRACT IN TREATMENT OF DENGUE PATIENTS
TLDR
Blood analysis reports, ultrasonographic findings, statistical results and patients recovery from d Dengue infection clearly shows the therapeutic role of Carica papaya leaf extracts in treating dengue infected patients. Expand
Carica papaya extract in dengue: a systematic review and meta-analysis
TLDR
The clinical value of improvement in platelet count or early discharge is unclear in the absence of more robust indicators of favourable clinical outcome, and current evidence is insufficient to comment on the role of CP extract in dengue. Expand
Carica Papaya; A Paired and Alternative Therapy of Dengue Fever
TLDR
Research reveals that juice of the leaves of the Carica papaya plant from the family Caricaceae help to increase the platelet levels and this alternative therapy that can be implement along with conventional treatment of dengue fever. Expand
Platelet enhancement by Carica papaya L. leaf fractions in cyclophosphamide induced thrombocytopenic rats is due to elevated expression of CD110 receptor on megakaryocytes.
TLDR
C. papaya leaf juice enhances the platelet count in chemotherapy-induced thrombocytopenia by increasing the expression of CD110 receptor on the megakaryocytes, and activating CD 110 receptor might be a viable strategy to increase the platelets production in individuals suffering from Thp. Expand
Comparative evaluation of platelet augmentation activity of Carica papaya leaf juice and hydrocortisone in thrombocytopenic rats
TLDR
Carica papaya leaf juice has more platelet increasing effect than hydrocortisone and this study reflects that Carica papaye leaf juice may be a potential candidate for further research leading to the development of a herbal therapeutic agent for thrombocytopenia manifested in diseases such as dengue. Expand
Evaluation of anti-dengue activity of Carica papaya aqueous leaf extract and its role in platelet augmentation
TLDR
The findings suggest that PLE can potentially be used as an antiviral agent, as it helps in platelet augmentation and exhibits antiviral activity against DENV. Expand
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References

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Dengue fever treatment with Carica papaya leaves extracts.
TLDR
From the patient feelings and blood reports it showed that Carica papaya leaves aqueous extract exhibited potential activity against Dengue fever, which can be further used as a strong natural candidate against viral diseases. Expand
Antifertility effects of aqueous extract of Carica papaya seeds in male rats.
TLDR
The data revealed that reversible sterility could be induced in male rats by papaya seeds aqueous extract treatment without adverse effects on libido and toxicological profile. Expand
Aqueous extract of Carica papaya leaves exhibits anti-tumor activity and immunomodulatory effects.
TLDR
The results suggest that the CP leaf extract may potentially provide the means for the treatment and prevention of selected human diseases such as cancer, various allergic disorders, and may also serve as immunoadjuvant for vaccine therapy. Expand
Pharmacognostic, physicochemical and phytochemical studies on Carica papaya Linn. leaves.
TLDR
The microscopic evaluation of leaves of Carica papaya Linn is dealt with to establish the salient diagnostic features for the leaf, which could be useful in setting some diagnostic indices for identification, authentication and preparation of the monograph of the plant. Expand
Effect of Carica papaya bark extract on oxidative stress parameters in testes of male albino rats
Summary: Carica papaya bark has contraceptive benefits when given at a high dose in male rats the mechanism at which it achieves this is yet to be fully understood. Forty male Wistar rats were used… Expand
Anti-inflammatory activities of ethanolic extract of Carica papaya leaves
TLDR
The results show that the extracts significantly (p <0.05) reduced paw oedema in the carrageenan test and the extract produced significant reduction in the amount of granuloma formed. Expand
Contraceptive evaluation and toxicological study of aqueous extract of the seeds of Carica papaya in male rabbits.
TLDR
The results suggest that the failure of contraceptive effects may be due to species specificity, relative resistance of the animals to the drug or lack of potency of the extract due to factors generally affect biological activity of the plant preparations. Expand
Blood pressure depression by the fruit juice of Carica papaya (L.) in renal and DOCA‐induced hypertension in the rat
TLDR
In one group of rats, the extract failed to depress the MAP in rats pretreated with propranolol, but atropine and noradrenaline pretreatment did not prevent the action of the extract on blood pressure. Expand
CARICA PAPAYA L.)
TLDR
Papaya is recalcitrant to tissue culture and an efficient in vitro regeneration protocol is therefore imperative for papaya improvement (virus resistance) through recombinant DNA technology. Expand
The natural history of dengue illness based on a study of hospitalised patients in Singapore.
TLDR
Dengue illness is a relatively benign self-limiting illness and it is reasonably safe to discharge patients when the PCs are on the rising trend and in the absence of clinical bleeding, instead of 100 x 10(3) ul-1. Expand
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