The effect of Calendula officinalis versus metronidazole on bacterial vaginosis in women: A double-blind randomized controlled trial

  title={The effect of Calendula officinalis versus metronidazole on bacterial vaginosis in women: A double-blind randomized controlled trial},
  author={Zahra Pazhohideh and Solmaz Mohammadi and Nosrat Bahrami and Faraz Mojab and Parvin Abedi and Elham Maraghi},
  journal={Journal of Advanced Pharmaceutical Technology \& Research},
  pages={15 - 19}
Bacterial vaginosis (BV) is a common disorder among women of reproductive age. [] Key Method In this study, 80 women of reproductive age with BV were randomly assigned to the C. officinalis (n = 40) or metronidazole (n = 40). Diagnosis of BV was confirmed when at least 3 of the 4 Amsel criteria were met (pH >4.5, whitish grey or thin homogeneous discharge, release of a fishy odor on adding 10% KOH, and detection of clue cells on microscopic examination).

Figures and Tables from this paper


Herbal medicines including H. perforatum, Z. multiflora, B. vulgaris and Allium sativum was found to be as effective as metronidazole with a fewer side effect and might be considered potential candidates to combat vaginosis.

Compare and evaluate the antibacterial efficacy of sodium hypochlorite and Calendula officinalis against Streptococcus mutans as a root canal irrigating solution: An in vivo study

Sodium hypochlorite remains the gold standard for bacterial elimination in root canal therapy; however, C. officinalis also has shown promising results and may require further investigation.

Bacterial Vaginosis: A Clinical Update with a Focus on Complementary and Alternative Therapies.

The purpose of this article is to review the state of the science regarding the safety and efficacy of alternative therapies for the treatment of bacterial vaginosis in nonpregnant women.

Do products containing Calendula officinalis have a positive role in treating uterine cervix disorders?

The aim of the current paper is to conduct a literature review regarding the benefits of Calendula officinalis in maximizing the healing process after local invasive procedures at the level of the uterine cervix as well as on human papilloma virus infection prevention.

Physical, chemical, and antioxidant stability studies of a topical formulation containing pot marigold (Calendula officinalis L.) flowers extract

Pot marigold flower extract (Calendula officinalis L.) has pharmacological properties due to the presence of various bioactive compounds. It is known that the extract has antioxidant,

Pharmacological Activity of Calendula officinalis: A systematic review

The pharmacological effects of Calendula officinalis at different researches are discussed, given that this contribution is important among researchers and the entire market, aiming at the therapeutic advancement.



Comparing the effects of Calendula officinalis and clotrimazole on vaginal Candidiasis: A randomized controlled trial

Calendula vaginal cream appears to have been effective in the treatment of vaginal Candidiasis and to have a delayed but greater long-term effect compared to clotrimazole.

Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis.

Comparison of vaginal gel isoflavones versus no topical treatment in vaginal dystrophy: results of a preliminary prospective study

  • C. TedeschiC. Benvenuti
  • Medicine
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
  • 2012
The combination of oral and topical isoflavones was shown to be more effective than oral treatment alone in reducing the problems of postmenopausal vaginal dystrophy.

Efficacy of maintenance therapy with topical boric acid in comparison with oral itraconazole in the treatment of recurrent vulvovaginal candidiasis.

Boric acid seems to be a valid and promising therapy both in the cure of the vaginal infection and in the prevention of relapses of recurrent vulvovaginal candidiasis, but its efficacy ends with the suspension of the therapy.

Antibacterial activity of antipsoriatic herbs: Cassia tora, Momordica charantia and Calendula officinalis

Among the various extracts, aqueous extracts exhibited highest activity especially against S. aureus which has been one of the organisms which aggravate conditions like psoriasis, in this study of antibacterial activity.

[The definition and epidemiology of bacterial vaginosis].

  • P. Mårdh
  • Medicine, Biology
    Revue francaise de gynecologie et d'obstetrique
  • 1993
The condition seldom occurs in prepubertal girls and post-menopausal women, suggesting an hormonal component in its etiology, and it has been proposed that nitrosamines from the abundant vaginal bacterial flora may be oncogenic, a correlation which needs to be proved.

Prevalence of bacterial vaginosis and impact of genital hygiene practices in non-pregnant women in zanjan, iran.

The data obtained suggests that the prevalence rate of BV is relatively high and could be affected by hygiene behaviors and certain socio-demographic characteristics, which indicate the need for comprehensive, scheduled programs of healthcare educations, aimed at reducing BV prevalence.

A New Vaginal Gel for Femalegenital Wellness and Disease Prevention: Rationale of a Multi-Herbal Derived Treatment on a High-Tech Pharmaceutical Perspective

Salvia, Melaleuca and Calendula have been selected by us among a certain number of natural compounds to be introduced in the formula of the vaginal gel, because their complementary properties synergize each other, achieving, altogether the best clinical results.

The Prevalence of Bacterial Vaginosis in the United States, 2001–2004; Associations With Symptoms, Sexual Behaviors, and Reproductive Health

Prevalence of BV is a common condition; 84% of women with BV did not report symptoms; BV could contribute to racial disparities in these infections.

Final report on the safety assessment of Calendula officinalis extract and Calendula officinalis.

  • F. A. Andersen
  • Medicine, Biology
    International journal of toxicology
  • 2001
Clinical testing of cosmetic formulations containing Calendula Officinalis Extract elicited little irritation or sensitization, and it is concluded that the available data are insufficient to support the safety of these ingredients in cosmetic formulations.