The effect of CYP2C19 substrate on the metabolism of melatonin in the elderly: A randomized, double-blind, placebo-controlled study.

@article{Huuhka2006TheEO,
  title={The effect of CYP2C19 substrate on the metabolism of melatonin in the elderly: A randomized, double-blind, placebo-controlled study.},
  author={Kaija Huuhka and Asko Riutta and Riina Haataja and Pauli Ylitalo and Esa Veli Juhani Leinonen},
  journal={Methods and findings in experimental and clinical pharmacology},
  year={2006},
  volume={28 7},
  pages={447-50}
}
The metabolism of melatonin to 6-sulphatoxymelatonin (aMT6S) and N-acetylserotonin (NAS) is catalyzed by cytochrome-P450 (CYP) isozymes CYP1A2 and CYP2C19 respectively. We studied the in vivo effect of CYP2C19 substrate (citalopram, omepratzole, or lansopratzole) on the metabolism of endogenous and exogenous melatonin by measuring the excretion of urinary aMT6S, the main metabolite of melatonin, and a reliable estimate of plasma melatonin in 15 insomniac psychogeriatric inpatients. The effect… CONTINUE READING