The effect of CXCL12 processing on CD34+ cell migration in myeloproliferative neoplasms.


Primary myelofibrosis (PMF) and polycythemia vera (PV) are chronic myeloproliferative neoplasms. PMF and, to a lesser degree, PV are characterized by constitutive mobilization of hematopoietic stem cells (HSC) and progenitor cells (HPC) into the peripheral blood (PB). The interaction between the chemokine CXCL12 and its receptor CXCR4 plays a pivotal role… (More)
DOI: 10.1158/0008-5472.CAN-09-3977


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