The effect of BE 2254 on the metabolic response stimulated by pyrogen in rabbits.

  • Z Szreder
  • Published 1993 in General pharmacology


1. Thermoregulatory effector processes were investigated in rabbits after treatment with 1 and 2 micrograms/kg of lipopolysaccharide Escherichia coli (LPS). Both doses produced a fever reaction resulting from stimulation of the metabolic rate and heat conservation responses. 2. BE 2254 administered in feverish rabbits reduced the metabolic as well as… (More)


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