The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial.

@article{Herrmann2007TheEO,
  title={The effect of B-vitamins on biochemical bone turnover markers and bone mineral density in osteoporotic patients: a 1-year double blind placebo controlled trial.},
  author={Markus Herrmann and Natalia Umanskaya and Lydia Traber and Heinrich E. Schmidt-Gayk and Wolfgang Menke and Gerd Lanzer and Markus Lenhart and Johannes Peter Schmidt and Wolfgang Herrmann},
  journal={Clinical chemistry and laboratory medicine},
  year={2007},
  volume={45 12},
  pages={1785-92}
}
BACKGROUND Hyperhomocysteinemia is a new risk factor for osteoporosis. This study analyzed the effect of a homocysteine (HCY)-lowering treatment in osteoporotic individuals. METHODS Osteoporotic subjects (n=47, 55-82 years) were treated with either a combination of 2.5 mg folate, 0.5 mg vitamin B(12) and 25 mg vitamin B(6) or placebo. Bone mineral density (BMD) at lumbar spine and hip was measured at baseline and after 1 year. Urinary desoxypyridinoline cross-links (DPD) and plasma levels of… CONTINUE READING
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