The effect of ACTH and cortisol on aldosterone and cortisol clearance and distribution in plasma and whole blood.

@article{Zipser1976TheEO,
  title={The effect of ACTH and cortisol on aldosterone and cortisol clearance and distribution in plasma and whole blood.},
  author={Robert D. Zipser and Paul F. Speckart and P K Zia and W A Edmiston and Francis Y. Lau and Richard Horton},
  journal={The Journal of clinical endocrinology and metabolism},
  year={1976},
  volume={43 5},
  pages={
          1101-9
        }
}
The mechanisms of increased aldosterone and cortisol metabolic clearance rates (MCR) following ACTH or cortisol administration were studied in 13 subjects undergoing cardiac catheterization and in 9 healthy controls. In control subjects, the MCR (plasma) of both steroids increased by 29% (aldosterone: from 936 +/- 57 to 1204 +/- 55 l/day/m2, cortisol: from 205 +/- 12 to 264 +/- 17 l/day/m2 +/- SE) after ACTH (12 units/h) for 1 to 4 h, and by 20 and 32%, respectively, after cortisol (12 mg/h… CONTINUE READING