The effect of ABCG2 and ABCC4 on the pharmacokinetics of methotrexate in the brain.

@article{Sane2014TheEO,
  title={The effect of ABCG2 and ABCC4 on the pharmacokinetics of methotrexate in the brain.},
  author={Ramola Sane and Shu-Pei Wu and Rong Zhang and James M. Gallo},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2014},
  volume={42 4},
  pages={537-40}
}
Methotrexate (MTX) is the cornerstone of chemotherapy for primary central nervous system lymphoma, yet how the blood-brain barrier (BBB) efflux transporters ABCG2 and ABCC4 influence the required high-dose therapy is unknown. To evaluate their role, we used four mouse strains, C57BL/6 (wild-type; WT), Abcg2(-/-), Abcc4(-/-), and Abcg2(-/-);Abcc4(-/-) (double knockout; DKO) to conduct brain microdialysis studies after single intravenous MTX doses of 50 mg/kg. When the area under the… CONTINUE READING
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