The effect of 2‐phenylisatogen on oxidative phosphorylation in rat liver mitochondria
@article{Sweetman1971TheEO, title={The effect of 2‐phenylisatogen on oxidative phosphorylation in rat liver mitochondria}, author={A. J. Sweetman and A. P. Green and M. Hooper}, journal={FEBS Letters}, year={1971}, volume={14} }
Oligomycin A, N&V’-dicyclohexylcarbodiimide (DCCD) and aurovertin are examples of compounds that have been shown to inhibit ATP synthesis in mitochondria [ 1,2] . These compounds have proved to be useful in the elucidation of the mechanism of reactions associated with electron transport and oxidative phosphorylation such as the ATP-dependent reduction of NAD+ by succinate and the ATP-dependent reduction of NADP+ by NADH [3]. We have examined the effect of the novel heterocyclic compound 2… CONTINUE READING
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References
SHOWING 1-5 OF 5 REFERENCES
A comparison of the effects of NN'-dicyclohexylcarbodi-imide, oligomycin A and aurovertin on enrgy-linked reactions in mitochondria and submitochondrial particles.
- Biology, Medicine
- The Biochemical journal
- 1968
- 75
- PDF
Studies of the energy-transfer system of submitochondrial particles. 2. Effects of oligomycin and aurovertin.
- Chemistry, Medicine
- European journal of biochemistry
- 1968
- 155
Determination of serum proteins by means of the biuret reaction.
- Medicine, Biology
- The Journal of biological chemistry
- 1949
- 13,284
- PDF
ANTIBIOTIC STUDIES. II. INHIBITION OF PHOSPHORYL TRANSFER IN MITOCHONDRIA BY OLIGOMYCIN AND AUROVERTIN.
- Chemistry, Medicine
- Biochemistry
- 1964
- 210