The effect of (a) neomycin and lactulose treatment on systemic and portal serum GABA levels in rats and (b) pH changes on [3H] GABA binding to isolated rat hepatocytes.


Recently it has been suggested that gamma-aminobutyric acid (GABA), a potent inhibitory neurotransmitter, may be involved in the pathogenesis of hepatic encephalopathy. If so, then therapeutic interventions that are known to improve or exacerbate the encephalopathic state should have significant effects on GABA homeostasis. In the present study, we… (More)


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