The effect Akt2 deletion on tumor development in Pten+/− mice

@inproceedings{Xu2012TheEA,
  title={The effect Akt2 deletion on tumor development in Pten+/− mice},
  author={P Xu and M Chen and S-M Jeon and X-d Peng and Nissim Hay},
  booktitle={Oncogene},
  year={2012}
}
The serine/threonine kinase Akt is frequently activated in human cancers and is considered an attractive therapeutic target. However, the relative contributions of the different Akt isoforms to tumorigenesis, and the effect of their deficiencies on cancer development are not well understood. We had previously shown that Akt1 deficiency is sufficient to markedly reduce the incidence of tumors in Pten+/− mice. Particularly, Akt1 deficiency inhibits endometrial carcinoma and prostate neoplasia in… CONTINUE READING
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