• Corpus ID: 19004389

The eff ect of social networks on the relation between Alzheimer ’ s disease pathology and level of cognitive function in old people : a longitudinal cohort study

@inproceedings{Bennett2004TheEE,
  title={The eff ect of social networks on the relation between Alzheimer ’ s disease pathology and level of cognitive function in old people : a longitudinal cohort study},
  author={David A. Bennett and Julie A. Schneider and Yuxiao Tang and Steven E. Arnold and Robert S. Wilson},
  year={2004}
}
Introduction Several clinicopathological studies over the past two decades have shown that many elderly people with extensive pathology of Alzheimer’s disease do not clinically manifest cognitive impairment. This ability to tolerate the pathology of this disease without obvious clinical consequences is increasingly referred to as cognitive or neural reserve. Identifi cation of factors associated with neural reserve has important implications for disease prevention. For example, one such factor… 
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SHOWING 1-10 OF 34 REFERENCES

Alzheimer's neurofibrillary pathology and the spectrum of cognitive function: Findings from the Nun Study

The Braak method of staging Alzheimer's disease pathology in 130 women ages 76–102 years who were participants in the Nun Study indicated that Alzheimer's neurofibrillary pathology is one of the neuropathologic substrates of mild cognitive impairments.

Cognitive reserve: Implications for diagnosis and prevention of Alzheimer’s disease

Some of the relevant literature of the noted associations between markers of cognitive reserve and AD are reviewed and the possible mechanisms that may explain these associations are discussed.

Pathological markers associated with normal aging and dementia in the elderly

It is proposed that hippocampal sclerosis, leukoencephalopathy, and multiple lacunae are possible markers of vascular dementia, when grouped together, which were significantly associated with dementia and occurred in 40% of demented subjects.

Neurofibrillary tangles mediate the association of amyloid load with clinical Alzheimer disease and level of cognitive function.

Findings are consistent with a sequence of pathologic events whereby the effect of amyloid deposition on clinical disease is mediated by neurofibrillary tangles.

Apolipoprotein E ε4 allele, AD pathology, and the clinical expression of Alzheimer’s disease

The APOE ε4 allele appears to be associated with the clinical manifestations of AD through an association with the pathologic hallmarks of AD rather than another mechanism.

Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people

Findings are consistent with a sequence of events whereby the e4 allele works through amyloid deposition and subsequent tangle formation to cause cognitive impairment.

Very Early Detection of Alzheimer Neuropathology and the Role of Brain Reserve in Modifying Its Clinical Expression

Findings are presented showing the importance of higher education and larger brain size in masking the underlying disease pathology.

Social resources and cognitive decline in a population of older African Americans and whites

Greater social resources, as defined by social networks and social engagement, are associated with reduced cognitive decline in old age.

The Rush Memory and Aging Project: Study Design and Baseline Characteristics of the Study Cohort

The long-term objective of the Rush Memory and Aging Project is to identify the postmortem indices linking genetic and environmental risk factors to the development of Alzheimer’s disease (AD). The