The economy of isometric force development, myosin isoenzyme pattern and myofibrillar ATPase activity in normal and hypothyroid rat myocardium.

@article{Holubarsch1985TheEO,
  title={The economy of isometric force development, myosin isoenzyme pattern and myofibrillar ATPase activity in normal and hypothyroid rat myocardium.},
  author={Ch. Holubarsch and R P Goulette and Raye Z Litten and Bradley J. Martin and Louis A. Mulieri and Norman R. Alpert},
  journal={Circulation research},
  year={1985},
  volume={56 1},
  pages={78-86}
}
Hypothyroidism was induced in Wistar-Kyoto rats by adding propylthiouracil to the drinking water (0.8 mg/ml). Initial heat, total activity-related heat, and resting heat rate were measured in left ventricular papillary muscle preparations of propylthiouracil-treated and control rats contracting isometrically at 12 beats/min (21 degrees C), using Hill type… CONTINUE READING