The early response to acid shock in Lactobacillus reuteri involves the ClpL chaperone and a putative cell wall-altering esterase.

@article{Wall2007TheER,
  title={The early response to acid shock in Lactobacillus reuteri involves the ClpL chaperone and a putative cell wall-altering esterase.},
  author={Torun Wall and Klara B{\aa}th and Robert A Britton and Hans Jonsson and James Versalovic and Stefan Roos},
  journal={Applied and environmental microbiology},
  year={2007},
  volume={73 12},
  pages={
          3924-35
        }
}
To be able to function as a probiotic, bacteria have to survive the passage through the gastrointestinal tract. We have examined survival and gene expression of Lactobacillus reuteri ATCC 55730 after a sudden shift in environmental acidity to a pH close to the conditions in the human stomach. More than 80% of the L. reuteri cells survived at pH 2.7 for 1 h. A genomewide expression analysis experiment using microarrays displayed 72 differentially expressed genes at this pH. The early response to… CONTINUE READING
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