The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals.

@article{Wikstrom2014TheEM,
  title={The early monocytic response to cytomegalovirus infection is MyD88 dependent but occurs independently of common inflammatory cytokine signals.},
  author={Matthew E. Wikstrom and Andrea Khong and Peter G Fleming and Rachel D Kuns and Paul J. Hertzog and Ian H Frazer and Christopher E Andoniou and Geoffrey R Hill and Mariapia A Degli-Esposti},
  journal={European journal of immunology},
  year={2014},
  volume={44 2},
  pages={409-19}
}
Cytomegalovirus latently infects myeloid cells; however, the acute effects of the virus on this cell subset are poorly characterised. We demonstrate that systemic cytomegalovirus infection induced rapid activation of monocytes in the bone marrow, characterised by upregulation of CD69, CD11c, Ly6C and M-CSF receptor. Activated bone marrow monocytes were more sensitive to M-CSF and less sensitive to granulocyte-monocyte colony stimulating factor in vitro, resulting in the generation of more… CONTINUE READING