The early manifestation, tumor-specific occurrence and prognostic significance of TGFBR2 aberrant splicing in oral carcinoma.

@article{Sivadas2014TheEM,
  title={The early manifestation, tumor-specific occurrence and prognostic significance of TGFBR2 aberrant splicing in oral carcinoma.},
  author={Vadakke Peringode Sivadas and Saakshi Gulati and Bipin T Varghese and Anita Balan and Sadhana Kannan},
  journal={Experimental cell research},
  year={2014},
  volume={327 1},
  pages={156-62}
}
Alternative splicing is an important mechanism that can disrupt cell cycle control resulting in tumorigenesis. Although many alterations of Transforming Growth Factor Beta (TGFβ) signaling are reported in cancers, the role of splice aberrations in destabilizing this signaling is the least understood mechanism. In this study, we compared TGFBR2 alternative splicing events in potentially malignant oral disorders (PMDs) and oral squamous cell carcinoma (OSCC) samples with those in normal samples… CONTINUE READING