The early kinetics of circulating pneumococcal-specific memory B cells following pneumococcal conjugate and plain polysaccharide vaccines in the elderly.

@article{Baxendale2010TheEK,
  title={The early kinetics of circulating pneumococcal-specific memory B cells following pneumococcal conjugate and plain polysaccharide vaccines in the elderly.},
  author={Helen E. Baxendale and Sheila M Keating and Marina Johnson and Jo Southern and Elizabeth Miller and David Goldblatt},
  journal={Vaccine},
  year={2010},
  volume={28 30},
  pages={4763-70}
}
In young children, polyvalent pneumococcal polysaccharide conjugate vaccines (PCVs) have been shown to offer advantage over plain polysaccharide vaccines (PPVs) in both immunogenicity and priming for memory responses. In the elderly, the potential benefit of conjugate vaccines is unclear. Here, we explore the early kinetics of serum antibody and circulating plasma and memory B cell responses to pneumococcal capsular polysaccharide (PPS) in older adults (n=37) immunised a PPV vaccine, Pneumovax… CONTINUE READING
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The immunogenicity of 7 - valent pneumococcal conjugate vaccine versus 23 - valent polysaccharide vaccine in adults aged 50 – 80 years

  • K Agematsu, S Hokibara, H Nagumo, A Komiyama
  • Clin Infect Dis
  • 2009

The humanspleen is amajor reservoir for long - livedvacciniavirus - specificmemory B cells

  • CF Jessup, H Baxendale, D Goldblatt, H Zola
  • Blood
  • 2008

Immunization for the elderly

  • S Black, H Shinefield, B Fireman, E Lewis, P Ray, Hansen
  • Am J Med Sci
  • 2007

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