The early expressed HIV-1 genes regulate DNMT1 expression.

  title={The early expressed HIV-1 genes regulate DNMT1 expression.},
  author={B. W. Youngblood and Norbert O Reich},
  volume={3 3},
DNA methylation-mediated transcriptional regulation is essential for human development and diverse diseases ensue when this process is dysregulated. Viruses, including HIV-1, alter the expression of human DNA methyltransferases (DNMTs) and various T cell-specific genes. Here we show that HIV-1 induction of DNMT1 results from overexpression of the early expressed HIV-1 proteins, and this induction is prevented with resveratrol which interferes with the transcription factor AP1 pathway. The HIV-1… CONTINUE READING
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