• Medicine
• Published in The Journal of physiology 2006
• DOI:10.1113/jphysiol.2006.108753

The early effects of chronic hypoxia on the cardiovascular system in the rat: role of nitric oxide.

@article{Walsh2006TheEE,
  title={The early effects of chronic hypoxia on the cardiovascular system in the rat: role of nitric oxide.},
  author={Martin P Walsh and Janice M Marshall},
  journal={The Journal of physiology},
  year={2006},
  volume={575 Pt 1},
  pages={
          263-75
        }
}

• Martin P Walsh, Janice M Marshall

Experiments were performed under Saffan anaesthesia on normoxic (N) rats and on chronically hypoxic rats exposed to 12% O2 for 1, 3 or 7 days (1, 3 or 7CH rats): N rats routinely breathed 21% O2 and CH rats 12% O2. The 1, 3 and 7CH rats showed resting hyperventilation relative to N rats, but baseline heart rate (HR) was unchanged and arterial blood pressure (ABP) was lowered. Femoral vascular conductance (FVC) was increased in 1 and 3CH rats, but not 7CH rats. When 1-7CH rats were acutely… CONTINUE READING

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