The early changes induced by isoproterenol in the endocardium and adjacent myocardium.

@article{NoronhaDutra1984TheEC,
  title={The early changes induced by isoproterenol in the endocardium and adjacent myocardium.},
  author={Alberto Augusto Noronha-Dutra and Eliel Steen and Neville J. Woolf},
  journal={The American journal of pathology},
  year={1984},
  volume={114 2},
  pages={
          231-9
        }
}
The acute phase of isoproterenol cardiotoxicity in the rat heart was studied by both scanning and transmission electron microscopy. The endocardium and immediate adjacent myocardium of the left ventricle and septum were chosen for examination because this area should be less affected by myocardial underperfusion. The initial damage, which was mainly to the endocardium, was well defined by 30 minutes; this damage consisted of endocardial cell contraction and separation with activated platelets… CONTINUE READING

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