The eIF4E subunits of two distinct trypanosomatid eIF4F complexes are subjected to differential post-translational modifications associated to distinct growth phases in culture.

@article{Pereira2013TheES,
  title={The eIF4E subunits of two distinct trypanosomatid eIF4F complexes are subjected to differential post-translational modifications associated to distinct growth phases in culture.},
  author={Mariana Machado Pereira and Amaranta Muniz Malvezzi and Larissa M{\'e}lo do Nascimento and Tamara de Carli da Costa Lima and Viviane de Souza Alves and M L Palma and Eden Ribeiro Freire and Danielle Maria Nascimento Moura and Christian Robottom Reis and Osvaldo P de Melo Neto},
  journal={Molecular and biochemical parasitology},
  year={2013},
  volume={190 2},
  pages={
          82-6
        }
}
The eukaryotic eIF4F complex, the cap binding complex, functions during translation initiation through interactions mediated by its three subunits (eIF4E, eIF4G and eIF4A), other initiation factors and the ribosome. In trypanosomatids, various eIF4E and eIF4G homologues were identified, with two eIF4F-like complexes confirmed (EIF4E4/EIF4G3/EIF4AI and EIF4E3/EIF4G4/EIF4AI). Here, the expression pattern of these complexes was investigated during Leishmania amazonensis and Trypanosoma brucei… CONTINUE READING
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