The eIF3 complex of Leishmania—subunit composition and mode of recruitment to different cap-binding complexes

@inproceedings{Meleppattu2015TheEC,
  title={The eIF3 complex of Leishmania—subunit composition and mode of recruitment to different cap-binding complexes},
  author={Shimi Meleppattu and Dikla Kamus-Elimeleh and Alexandra Zinoviev and Shahar Cohen-Mor and Irit Orr and Michal Shapira},
  booktitle={Nucleic acids research},
  year={2015}
}
Eukaryotic initiation factor 3 (eIF3) is a multi-protein complex and a key participant in the assembly of the translation initiation machinery. In mammals, eIF3 comprises 13 subunits, most of which are characterized by conserved structural domains. The trypanosomatid eIF3 subunits are poorly conserved. Here, we identify 12 subunits that comprise the Leishmania eIF3 complex (LeishIF3a-l) by combining bioinformatics with affinity purification and mass spectrometry analyses. These results… CONTINUE READING
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