The eIF2α serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress

@inproceedings{Rajesh2016TheES,
  title={The eIF2α serine 51 phosphorylation-ATF4 arm promotes HIPPO signaling and cell death under oxidative stress},
  author={K Thimmulappa Rajesh and Jothilatha Krishnamoorthy and Jyotsana Gupta and Urszula Kazimierczak and Andreas I. Papadakis and Zhilin Deng and Stephen Wang and Shinji Kuninaka and Antonis E. Koromilas},
  booktitle={Oncotarget},
  year={2016}
}
The HIPPO pathway is an evolutionary conserved regulator of organ size that controls both cell proliferation and death. This pathway has an important role in mediating cell death in response to oxidative stress through the inactivation of Yes-associated protein (YAP) and inhibition of anti-oxidant gene expression. Cells exposed to oxidative stress induce the phosphorylation of the alpha (α) subunit of the translation initiation factor eIF2 at serine 51 (eIF2αP), a modification that leads to the… CONTINUE READING

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