The dyslexia-associated gene KIAA0319 encodes highly N- and O-glycosylated plasma membrane and secreted isoforms.

@article{VelayosBaeza2008TheDG,
  title={The dyslexia-associated gene KIAA0319 encodes highly N- and O-glycosylated plasma membrane and secreted isoforms.},
  author={Antonio Velayos-Baeza and Claudio Toma and Silvia Paracchini and Anthony P Monaco},
  journal={Human molecular genetics},
  year={2008},
  volume={17 6},
  pages={859-71}
}
The KIAA0319 gene has been recently associated with developmental dyslexia and shown to be involved in neuronal migration. The deduced KIAA0319 protein contains several polycystic kidney disease (PKD) domains which may mediate the interaction between neurons and glial fibres during neuronal migration. We have previously reported the presence of several alternative splicing variants, some of which are predicted to affect the deduced protein. In this study, we over-expressed constructs containing… CONTINUE READING
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