The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins, and role in neurite outgrowth

@inproceedings{Ghiani2010TheDC,
  title={The dysbindin-containing complex (BLOC-1) in brain: developmental regulation, interaction with SNARE proteins, and role in neurite outgrowth},
  author={CA Ghiani and Marta Starcevic and IA Rodriguez-Fernandez and Ramin Nazarian and VT Cheli and L. L. Chan and JS Malvar and Jean de Vellis and Chiara Sabatti and EC Dell’Angelica},
  booktitle={Molecular Psychiatry},
  year={2010}
}
Previous studies have implicated DTNBP1 as a schizophrenia susceptibility gene and its encoded protein, dysbindin, as a potential regulator of synaptic vesicle physiology. In this study, we found that endogenous levels of the dysbindin protein in the mouse brain are developmentally regulated, with higher levels observed during embryonic and early postnatal ages than in young adulthood. We obtained biochemical evidence indicating that the bulk of dysbindin from brain exists as a stable component… CONTINUE READING
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