The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells.

@article{Joshi2010TheDI,
  title={The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells.},
  author={Sanket Joshi and Swetha Perera and Jayne Gilbert and Charlotte M. Smith and Anna Mariana and Christopher P Gordon and Jennette A Sakoff and Adam McCluskey and Phillip J Robinson and Antony W. Braithwaite and Megan Chircop},
  journal={Molecular cancer therapeutics},
  year={2010},
  volume={9 7},
  pages={1995-2006}
}
The endocytic protein dynamin II (dynII) participates in cell cycle progression and has roles in centrosome cohesion and cytokinesis. We have described a series of small-molecule inhibitors of dynamin [myristyl trimethyl ammonium bromides (MiTMAB)] that competitively interfere with the ability of dynamin to bind phospholipids and prevent receptor-mediated… CONTINUE READING