The dynamin GTPase OPA1: more than mitochondria?

  title={The dynamin GTPase OPA1: more than mitochondria?},
  author={Pascale B{\'e}lenguer and Luca Pellegrini},
  journal={Biochimica et biophysica acta},
  volume={1833 1},
The studies addressing the molecular mechanisms governing mitochondrial fusion and fission have brought to light a small group of dynamin-like GTPases (Guanosine-Triphosphate hydrolase) as central regulators of mitochondrial morphology and cristae remodeling, apoptosis, calcium signaling, and metabolism. One of them is the mammalian OPA1 (Optic atrophy 1) protein, which resides inside the mitochondrion anchored to the inner membrane and, in a cleaved form, is associated to oligomeric complexes… CONTINUE READING
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