The dynamics of the lung fluid filtration system in dogs with edema.

@article{Gee1980TheDO,
  title={The dynamics of the lung fluid filtration system in dogs with edema.},
  author={Marlys H. Gee and James A. Spath},
  journal={Circulation research},
  year={1980},
  volume={46 6},
  pages={
          796-801
        }
}
SUMMARY We studied the relationship between pulmonary microvasculature fluid filtration pressures and lung lymph flow rate (Q L) as filtration pressures increased to determine why lungs with functional lymphatics become edematous and, as filtration pressures decreased, to determine the effect of edema formation on lymphatic function. Edema was induced by rapid intravenous infusion of neutralized Ringer's solution in a volume equivalent to 30% of body weight in seven anesthetized dogs. Pulmonary… 
23 Citations

Figures and Tables from this paper

Effects of dextran 70 on hemodynamics and lung liquid and protein exchange in awake sheep.

TLDR
The effect of intravenous dextran 70 infusion on lung liquid and protein exchange and pulmonary hemodynamics and lymph dynamics was studied to determine whether its effects were due to altered hemodynamics or to altered microvascular permeability.

Transmigration of fluid rapidly infused into dogs with renal blood vessels ligation and increased pulmonary capillary permeability.

TLDR
Results show that in the dogs without increased pulmonary capillary permeability excessive fluid is mainly excreted as urine (group F) or transudates into the abdominal cavity (group LF), but in the Dogs with increased pulmonaryCapillary permeable (group OF) excessive fluid easily and rapidly transudated into the pulmonary interstitium, resulting in pulmonary edema.

Impeded alveolar-capillary gas transfer with saline infusion in heart failure.

TLDR
Hindrance to gas transfer with salt infusion in CHF, despite an increase in V(C) and no variations in pulmonary hydrostatic forces, indicates an upregulation in sodium transport from blood to interstitium with interstitial edema.

Pulmonary edema formation with myocardial infarction and left atrial hypertension: intravascular and extravascular pulmonary fluid volumes.

TLDR
It is concluded that coronary ligation can increase EVLW, independent of microvascular hydrostatic pressure, and provides a partial explanation for the occasional disparity between left heart dynamics and the chest radiograph in acute myocardial infarction.

Alveolar and lung liquid clearance in the absence of pulmonary blood flow in sheep.

TLDR
The effect of removing pulmonary blood flow on the clearance of excess liquid and protein from the air spaces and interstitium of the normal lung was studied in anesthetized ventilated sheep and the removal of 125I-albumin from the lung was not altered.

Capillary fluid filtration. Starling forces and lymph flow.

TLDR
The basic forces responsible for maintaining fluid balance between the microcirculation and interstitium are defined, and physiologists have termed tissue pressure, capillary pressure, plasma colloidal osmotic (TTP), and tissue colloidal Osmotic pressure as Starling forces, however, a mathematical relationship between those forces was not formulated by Starling.

References

SHOWING 1-10 OF 20 REFERENCES

Effect of Increased Vascular Pressure on Lung Fluid Balance in Unanesthetized Sheep

TLDR
The major contributions to the safety factor appeared to be a sensitive and efficient lymph pump coupled to a washout of interstitial protein in the interstitial fluid at the filtration site.

The flow and composition of pulmonary and systemic lymph in dogs with edema.

TLDR
It is concluded that lymph flow rate and composition reflect events occurring in the microvasculature whether or not edema is present.

Effect of Positive Pressure Breathing on Lung Lymph Flow and Water Content in Sheep

TLDR
It is concluded that moderate CPAPB does not measurably affect the steady state lung fluid balance and it appears that the fraction of increased alveolar pressure transmitted to the microvessels was via the perimicrovascular fluid rather than through solid tissue contact.

Pulmonary capillary pressure and filtration coefficient in the isolated perfused lung.

TLDR
An “isogravimetric” method was used to estimate the pulmonary capillary pressure, to determine the arterial and venous resistances in the isolated perfused lobe of a dog’s lung, and to determine its filtration coefficient.

The forces regulating fluid filtration in the lung.

  • N. Staub
  • Medicine
    Microvascular research
  • 1978

Effect of lung inflation on perivascular cuff fluid volume in isolated dog lung lobes.

Cardiopulmonary Effects of Pulmonary Venous Hypertension with Special Reference to Pulmonary Lymphatic Flow

TLDR
Many of the usual functional and structural changes often found in lungs of patients with mitral stenosis, except for hemosiderosis, were not observed in the authors' experimental animals although the extent of the supravalvular stenosis produced was marked.

The relationship between right duct lymph flow and extravascular lung water in dogs given alpha-naphthylthiourea.

TLDR
In ANTU-induced pulmonary edema right duct lymph flow was directly related toextravascular lung water with the highest flows occurring with severe edema, and the absence of a rapid increase in lymph flow with small increases in extravascular water may be due to early sequestration of fluid in the alveolar space.

Protein composition of lung fluids in acute alloxan edema in dogs.

TLDR
It is concluded that in alloxan-induced pulmonary edema the lung fluids contain high concentrations of protein and the alveolar epithelial membrane becomes freely permeable to protein molecules.

Measurement of Pulmonary Edema

TLDR
The isotope transit time method is concluded that the edema water is determined more accurately when pulmonary edema is due to elevated pulmonary venous pressure than when due to increased vascular permeability.