The dynamics of mouse cytomegalovirus-specific CD4 T cell responses during acute and latent infection.

@article{Walton2008TheDO,
  title={The dynamics of mouse cytomegalovirus-specific CD4 T cell responses during acute and latent infection.},
  author={Senta Maria Walton and Philippe Rudolf Wyrsch and Michael W Munks and Albert Zimmermann and Hartmut Hengel and Ann B Hill and Annette Oxenius},
  journal={Journal of immunology},
  year={2008},
  volume={181 2},
  pages={
          1128-34
        }
}
The dynamics of mouse cytomegalovirus (MCMV)-specific CD4 T cell responses and the mechanisms by which these cells contribute to viral control are not well understood, mainly due to lack of appropriate tools to characterize MCMV-specific CD4 T cells. We therefore generated MCMV-specific CD4 T cell hybridomas, then used an MCMV expression library and overlapping peptides to identify CD4 T cell epitopes. We used these novel tools to study the long-term kinetics and organ distribution of MCMV… CONTINUE READING
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