The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease

@article{Stewart2015TheDO,
  title={The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease},
  author={James B Stewart and Patrick F. Chinnery},
  journal={Nature Reviews Genetics},
  year={2015},
  volume={16},
  pages={530-542}
}
Common genetic variants of mitochondrial DNA (mtDNA) increase the risk of developing several of the major health issues facing the western world, including neurodegenerative diseases. In this Review, we consider how these mtDNA variants arose and how they spread from their origin on one single molecule in a single cell to be present at high levels throughout a specific organ and, ultimately, to contribute to the population risk of common age-related disorders. mtDNA persists in all aerobic… CONTINUE READING
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