The dynamics of chromosome organization and gene regulation.

  title={The dynamics of chromosome organization and gene regulation.},
  author={David L. Spector},
  journal={Annual review of biochemistry},
With the sequence of the human genome now complete, studies must focus on how the genome is functionally organized within the confines of the cell nucleus and the dynamic interplay between the genome and its regulatory factors to effectively control gene expression and silencing. In this review I describe our current state of knowledge with regard to the organization of chromosomes within the nucleus and the positioning of active versus inactive genes. In addition, I discuss studies on the… CONTINUE READING
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D ow nl oa de d fr om w w w .a nn ua lr ev ie w s. or g by C ol d Sp ri ng H ar bo r L ab or at or y on

  • CM Clemson, JA McNeill, HF Willard
  • 1996

Transcription Mechanisms and Regulation, ed

  • SM Lobo, N. Hernandez
  • 1994
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