The dynamics of chromosome organization and gene regulation.

@article{Spector2003TheDO,
  title={The dynamics of chromosome organization and gene regulation.},
  author={David L. Spector},
  journal={Annual review of biochemistry},
  year={2003},
  volume={72},
  pages={573-608}
}
With the sequence of the human genome now complete, studies must focus on how the genome is functionally organized within the confines of the cell nucleus and the dynamic interplay between the genome and its regulatory factors to effectively control gene expression and silencing. In this review I describe our current state of knowledge with regard to the organization of chromosomes within the nucleus and the positioning of active versus inactive genes. In addition, I discuss studies on the… CONTINUE READING
Highly Influential
This paper has highly influenced 12 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS

Citations

Publications citing this paper.
Showing 1-10 of 142 extracted citations

References

Publications referenced by this paper.
Showing 1-2 of 2 references

D ow nl oa de d fr om w w w .a nn ua lr ev ie w s. or g by C ol d Sp ri ng H ar bo r L ab or at or y on

  • CM Clemson, JA McNeill, HF Willard
  • DYNAMICS OF GENE REGULATION A
  • 1996

Transcription Mechanisms and Regulation, ed

  • SM Lobo, N. Hernandez
  • 1994
1 Excerpt

Similar Papers

Loading similar papers…