The dynamics of cancer chromosomes and genomes

@article{Ye2007TheDO,
  title={The dynamics of cancer chromosomes and genomes},
  author={Christine J. Ye and G. Liu and Steven W. Bremer and Henry H. Q. Heng},
  journal={Cytogenetic and Genome Research},
  year={2007},
  volume={118},
  pages={237 - 246}
}
  • C. YeG. Liu H. Heng
  • Published 1 November 2007
  • Biology
  • Cytogenetic and Genome Research
A key feature of cancer chromosomes and genomes is their high level of dynamics and the ability to constantly evolve. This unique characteristic forms the basis of genetic heterogeneity necessary for cancer formation, which presents major obstacles to current cancer diagnosis and treatment. It has been difficult to integrate such dynamics into traditional models of cancer progression. In this conceptual piece, we briefly discuss some of the recent exciting progress in the field of cancer… 

Figures from this paper

Patterns of Genome Dynamics and Cancer Evolution

  • H. HengJ. Stevens C. Ye
  • Biology
    Cellular oncology : the official journal of the International Society for Cellular Oncology
  • 2008
The importance of the chromosome versus the gene as a causative agent in cancer formation has sparked a heated debate and the existence of an overwhelming amount of non-clonal chromosome aberrations (NCCAs) has been identified in patients and cancer progression models.

Cancer genome evolution

The genome theory is presented as an emerging holistic theory that covers multiple levels of genetic and non-genetic alteration by shifting emphasis onto genome-defined (sequence and three-dimensional topology) system inheritance and suggests that understanding cancer evolution holds the key to understanding other complex diseases and evolutionary theory in general.

Chromosomal instability (CIN): what it is and why it is crucial to cancer evolution

This review discusses multiple aspects of CIN including its definitions, methods of measuring, and some common misconceptions and applies the genome-based evolutionary theory to propose a general mechanism for CIN to unify the diverse molecular causes.

The inheritance of heterogeneity

One important characteristic of solid tumors is heterogeneity at multiple levels of genetic and non-genetic organization, which can include gene mutations, epigenetic alterations, copy number changes, and chromosomal aberrations, which contribute as parts of a genome-defined system.

Chromosomal Instability (CIN) in Cancer

By applying the genome theory of cancer evolution, CIN is defined and clarified, its importance in macro-cellular evolutionary selection is synthesised, its potential implications are discussed and diverse molecular mechanisms under the evolutionary mechanism of cancer are unify.

Evolutionary mechanisms and diversity in cancer.

Insights on processes of evolutionary tumor growth

A focus shift back on cytogenetic and cytogenomic alterations is called for in monitoring population growth, identifying the emergence of new subpopulations and studying patterns of evolutionary dynamics under a new, holistic conceptual framework for cancer research.

The evolutionary mechanism of cancer

The newly established genome theory is introduced here describing how somatic cells evolve within individual patients and the recently identified relationship between the evolutionary mechanism and a large number of diverse individual molecular mechanisms is discussed.
...

References

SHOWING 1-10 OF 71 REFERENCES

Cancer progression by non‐clonal chromosome aberrations

It is argued that even though stochastic changes can be detected at various levels of genetic organization, such as at the gene level and epigenetic level, it is primarily detected at the chromosomal or genome level, and thus, NCCA‐mediated genomic variation plays a dominant role in cancer progression.

Clonal and non-clonal chromosome aberrations and genome variation and aberration.

This study raises challenging questions regarding the concept of cancer evolution driven by stochastic chromosomal aberration mediated genome irregularities that could have repercussions reaching far beyond cancer and organismal genomes.

Cancer genome sequencing: the challenges ahead.

  • H. Heng
  • Biology
    BioEssays : news and reviews in molecular, cellular and developmental biology
  • 2007
It is suggested that cancer is a disease of probability and the most-challenging issue to the TCGA project, as well as the development of general strategies for fighting cancer, lie at the conceptual level.

Stochastic cancer progression driven by non‐clonal chromosome aberrations

The discovery of “transitional CCAs” during in vitro immortalization clearly demonstrates that karyotypic evolution in solid tumors is not a continuous process, and genomic instability generated NCCAs are a key driving force in cancer progression.

Imaging genome abnormalities in cancer research

This review discusses the identification of defective mitotic figures (DMF), a new type of chromosomal aberration capable of monitoring condensation defects in cancer; the establishment of a method that uses Non-Clonal Chromosomal Aberrations (NCCAs) as an index to monitor genomic instability.

Chromosome breakage syndromes and cancer.

  • N. Duker
  • Medicine, Biology
    American journal of medical genetics
  • 2002
Progress in defining the molecular genetics of these entities suggests that many of them are disorders of DNA recombination, and each defect involves a separate protein in these complex pathways.

Can chromosomal instability initiate tumorigenesis?

Recurrent chromosome aberrations in cancer.

Array CGH technologies and their applications to cancer genomes

The need for high-resolution analysis is discussed as well as the importance of studying early-stage disease to discover genetic alterations that may be causal to cancer progression and aetiology.

Aneuploidy, the somatic mutation that makes cancer a species of its own.

Biochemical and biological analyses of aneuploidy and gene mutation show that aneu ploidy is probably the only mutation that can explain all aspects of carcinogenesis, and the aneuPLoidy hypothesis offers new prospects of cancer prevention and therapy.
...