The dynamics of acute inflammation.

@article{Kumar2004TheDO,
  title={The dynamics of acute inflammation.},
  author={Rukmini Kumar and G. Clermont and Y. Vodovotz and C. Chow},
  journal={Journal of theoretical biology},
  year={2004},
  volume={230 2},
  pages={
          145-55
        }
}
When the body is infected, it mounts an acute inflammatory response to rid itself of the pathogens and restore health. Uncontrolled acute inflammation due to infection is defined clinically as sepsis and can culminate in organ failure and death. We consider a three-dimensional ordinary differential equation model of inflammation consisting of a pathogen, and two inflammatory mediators. The model reproduces the healthy outcome and diverse negative outcomes, depending on initial conditions and… Expand
THE ACUTE INFLAMMATORY RESPONSE IN DIVERSE SHOCK STATES
TLDR
A mathematical model incorporating major elements of the acute inflammatory response in C57Bl/6 mice was developed and found that a single model with different initiators including the autonomic system could describe the response to various insults. Expand
MODELING THERAPEUTIC INTERVENTION IN SEPSIS
Inflammation is the physiological response to infection and tissue injury. It is characterized by release of proteins called cytokines and other mediators produced by cells of the immune system.Expand
A reduced mathematical model of the acute inflammatory response: I. Derivation of model and analysis of anti-inflammation.
TLDR
This work derives a reduced conceptual model for the acute inflammatory response to infection, built up from consideration of direct interactions of fundamental effectors, to explore the importance of dynamic anti-inflammation in promoting resolution of infection and homeostasis. Expand
IN SILICO MODELS OF ACUTE INFLAMMATION IN ANIMALS
TLDR
A mathematical model is constructed using ordinary differential equations that encompass the dynamics of cells and cytokines of the acute inflammatory response, as well as global tissue dysfunction and may provide insights into the complex dynamics of acute inflammation in a manner that can be tested in vivo using many fewer animals than has been possible previously. Expand
General Model of Inflammation
TLDR
It is found nonaggressive bacteria are able to initiate chronic inflammation and it is proposed why anti-inflammatory cytokine therapy may not be effective in resolving this inflammation. Expand
Deciphering the complexity of acute inflammation using mathematical models
TLDR
Modeling may help in understanding the complex interactions among the components of inflammation and response to stress, and therefore aid in the development of novel therapies and diagnostics. Expand
Sepsis: multiple abnormalities, heterogeneous responses, and evolving understanding.
TLDR
Given the complexity of sepsis, biomarkers and mathematical models offer potential guidance once they have been carefully validated to provide a framework for understanding the complex and current challenges of managing the septic patient. Expand
Sepsis progression and outcome: a dynamical model
TLDR
This work uses the mass-specific rate of blood circulation (SRBC), a correlate of the body mass index, to build a differential equation model of circulation, infection, organ damage, and recovery, and predicts that deviations from normal SRBC correlate with disease progression and adverse outcome. Expand
Mathematical modeling of energy consumption in the acute inflammatory response.
TLDR
This work presents a differential equations model that incorporates the dynamics of ATP, nitric oxide, and lactate accompanying an acute inflammatory response and employs this model to explore their roles in shaping this response and applies it to study alterations in theinflammatory response and survival outcomes in metabolically altered conditions. Expand
Mathematical Model of Innate and Adaptive Immunity of Sepsis: A Modeling and Simulation Study of Infectious Disease
TLDR
Simulated results in silico have shown that adaptive immunity has significant impacts on the outcomes of sepsis progression, and further investigation has found that the intervention timing, intensity of anti-inflammatory cytokines, and initial pathogen load are highly predictive of outcomes of a sepsi episode. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 120 REFERENCES
Inflammatory cell activation in sepsis.
TLDR
This review focuses on the mechanisms whereby inflammatory cells are activated, how the regulatory system may misfunction and how it may in the future be manipulated to therapeutic advantage. Expand
Anti-inflammatory therapies in sepsis and septic shock
TLDR
Clinical trials in sepsis have focused on inhibiting specific host pro-inflammatory mediators (e.g., TNF, interleukins) and pooling the results of these trials suggest that this approach has a marginal effect, supporting a role for excessive inflammation inSepsis. Expand
The pathophysiology and treatment of sepsis.
TLDR
This review examines evolving concepts of sepsis and discusses new and potential therapies, including therapy with activated protein C, stringent control of blood glucose, and early goal-directed therapy to treat cellular oxygen deficit. Expand
Serum cytokine levels in human septic shock. Relation to multiple-system organ failure and mortality.
TLDR
TNF and IL-6 serum levels are higher in septic than in nonseptic shock, but the persistence of TNF andIL-6 in the serum rather than peak levels of cytokines predicts a poor outcome in patients with shock. Expand
Sepsis: a pro- and anti-inflammatory disequilibrium syndrome.
  • M. Pinsky
  • Medicine
  • Contributions to nephrology
  • 2001
TLDR
Both the pro- and anti-inflammatory arms have protective and destructive aspects, making their modulation by treatment less predictable than if their actions were purely beneficial or detrimental. Expand
A New Paradigm for the Treatment of Sepsis: Is It Time To Consider Combination Therapy?
TLDR
This study, the largest clinical trial for sepsis to date, randomly assigned more than 3000 patients to receive one of several doses of a Fab component of a monoclonal antibody against tumor necrosis factor (TNF) or placebo and there was a small improvement in mortality that mirrored the data presented in their meta-analysis. Expand
Toward a theory regarding the pathogenesis of the systemic inflammatory response syndrome: what we do and do not know about cytokine regulation.
  • R. Bone
  • Medicine
  • Critical care medicine
  • 1996
TLDR
While cytokines are generally viewed as a destructive development in the patient that generally leads to multiple organ dysfunction, cytokines also protect the body when localized and it will be necessary to study the positive effects of cytokines while also studying their role in causing SIRS. Expand
Sepsis Research in the Next Millennium: Concentrate on the Software Rather than the Hardware
TLDR
It is concluded that sepsis research needs new perspectives that allow it to handle the complex interactions occurring during the disease process and the ideas and techniques of non-linear systems theory are suitable tools for the analysis of complex and dynamic diseases like SIRS and sepsi. Expand
Reducing mortality in sepsis: new directions
Considerable progress has been made in the past few years in the development of therapeutic interventions that can reduce mortality in sepsis. However, encouraging physicians to put the results ofExpand
Mechanisms of neutrophil‐induced parenchymal cell injury
  • H. Jaeschke, C. Wayne Smith
  • Biology, Medicine
  • Journal of leukocyte biology
  • 1997
TLDR
This review summarizes recent advances in the understanding of neutrophil‐induced parenchymal cell injury using the liver as an example and discusses the involvement of various adhesion molecules, the role of cytokines and chemokines in the pathophysiology, as well as the effects of proteases and reactive oxygen species released by neutrophils. Expand
...
1
2
3
4
5
...