The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesis.

@article{Rix2004TheDS,
  title={The dynamic structure of jadomycin B and the amino acid incorporation step of its biosynthesis.},
  author={Uwe Rix and Jianting Zheng and Lily L. Remsing Rix and Lisa M Greenwell and Keqian Yang and J. 0. Taylor Rohr},
  journal={Journal of the American Chemical Society},
  year={2004},
  volume={126 14},
  pages={4496-7}
}
Jadomycin B, an antifungal antibiotic with a unique 8H-benz[b]oxazolo[3,2-f]phenanthridine pentacyclic skeleton produced by the bacterium Streptomyces venezuelae ISP 5230, exists in a dynamic equilibrium of two diastereomers differing in the configuration of C-3a. Several novel jadomycins with various amino acid-derived 1-side chains could be generated, by replacing isoleucine in the production medium of S. venezuelae with other amino acids. These two findings led to the conclusion that a… CONTINUE READING

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