The dynamic range of the human metabolome revealed by challenges

@article{Krug2012TheDR,
  title={The dynamic range of the human metabolome revealed by challenges},
  author={S. Krug and G. Kastenm{\"u}ller and F. St{\"u}ckler and M. Rist and T. Skurk and M. Sailer and Johannes Raffler and W. R{\"o}misch-Margl and J. Adamski and C. Prehn and T. Frank and K. Engel and T. Hofmann and B. Luy and Ralf Zimmermann and F. Moritz and P. Schmitt-Kopplin and J. Krumsiek and W. Kremer and F. Huber and U. Oeh and F. Theis and W. Szymczak and H. Hauner and K. Suhre and H. Daniel},
  journal={The FASEB Journal},
  year={2012},
  volume={26},
  pages={2607 - 2619}
}
Metabolic challenge protocols, such as the oral glucose tolerance test, can uncover early alterations in metabolism preceding chronic diseases. Nevertheless, most metabolomics data accessible today reflect the fasting state. To analyze the dynamics of the human metabolome in response to environmental stimuli, we submitted 15 young healthy male volunteers to a highly controlled 4 d challenge protocol, including 36 h fasting, oral glucose and lipid tests, liquid test meals, physical exercise, and… Expand
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