The dynamic provision of different energy substrates improves development of one-cell random-bred mouse embryos in vitro.

@article{Brown1992TheDP,
  title={The dynamic provision of different energy substrates improves development of one-cell random-bred mouse embryos in vitro.},
  author={Julie V. Brown J. Brown and David G Whittingham},
  journal={Journal of reproduction and fertility},
  year={1992},
  volume={95 2},
  pages={503-11}
}
Preliminary observations showed that one-cell embryos from random-bred MF1 mice avoid cleavage arrest at the two-cell stage ('in vitro two-cell block') when cultured in modified M16 culture medium containing lactate and pyruvate but lacking glucose. The roles of lactate, pyruvate and glucose during preimplantation development of embryos from random-bred mice in vitro were therefore examined. When all three substrates were present continuously during culture, one-cell embryos arrested at the two… CONTINUE READING

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