The dynamic nature of RNA as key to understanding riboswitch mechanisms.

@article{Haller2011TheDN,
  title={The dynamic nature of RNA as key to understanding riboswitch mechanisms.},
  author={Andrea Haller and Marie F. Souli{\`e}re and Ronald Micura},
  journal={Accounts of chemical research},
  year={2011},
  volume={44 12},
  pages={1339-48}
}
Riboswitches are gene regulation elements within RNA that recognize specific metabolites. They predominantly occur in the untranslated leader regions of bacterial messenger RNA (mRNA). Upon metabolite binding to the aptamer domain, a structural change in the adjoining downstream expression platform signals "on" or "off" for gene expression. Researchers have achieved much progress in characterizing ligand-bound riboswitch states at the molecular level; an impressive number of high-resolution… CONTINUE READING
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