The dynamic kinetochore-microtubule interface

@article{Maiato2004TheDK,
  title={The dynamic kinetochore-microtubule interface},
  author={H. Maiato and J. DeLuca and E. Salmon and W. Earnshaw},
  journal={Journal of Cell Science},
  year={2004},
  volume={117},
  pages={5461 - 5477}
}
The kinetochore is a control module that both powers and regulates chromosome segregation in mitosis and meiosis. The kinetochore-microtubule interface is remarkably fluid, with the microtubules growing and shrinking at their point of attachment to the kinetochore. Furthermore, the kinetochore itself is highly dynamic, its makeup changing as cells enter mitosis and as it encounters microtubules. Active kinetochores have yet to be isolated or reconstituted, and so the structure remains enigmatic… Expand
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