The dynamic control of signal transduction networks in cancer cells

  title={The dynamic control of signal transduction networks in cancer cells},
  author={Walter Kolch and Melinda Halasz and Marina Granovskaya and Boris N. Kholodenko},
  journal={Nature Reviews Cancer},
Cancer is often considered a genetic disease. However, much of the enormous plasticity of cancer cells to evolve different phenotypes, to adapt to challenging microenvironments and to withstand therapeutic assaults is encoded by the structure and spatiotemporal dynamics of signal transduction networks. In this Review, we discuss recent concepts concerning how the rich signalling dynamics afforded by these networks are regulated and how they impinge on cancer cell proliferation, survival… 

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  • Biology, Environmental Science
    Nature Reviews Molecular Cell Biology
  • 2006
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