The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm.

@article{Smith2005TheDO,
  title={The duality of beta-catenin function: a requirement in lens morphogenesis and signaling suppression of lens fate in periocular ectoderm.},
  author={April N. Smith and L D Miller and Ni Song and Makoto Mark Taketo and Richard A Lang},
  journal={Developmental biology},
  year={2005},
  volume={285 2},
  pages={477-89}
}
In the current analysis, we have investigated both the cytoskeletal and signaling roles of beta-catenin during the early phases of lens development using conditional loss- and gain-of-function strategies. Conditional loss of beta-catenin in the presumptive lens does not perturb the normal sequential appearance of lens fate markers but results in a dramatic failure of the coordinated epithelial cell behavior that constitutes lens morphogenesis. Similarly, loss-of-function for Lrp6, the Wnt… CONTINUE READING

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