The dual role of ubiquitin-like protein Urm1 as a protein modifier and sulfur carrier

  title={The dual role of ubiquitin-like protein Urm1 as a protein modifier and sulfur carrier},
  author={Fengbin Wang and Meiruo Liu and Rui Qiu and Chaoneng Ji},
  journal={Protein & Cell},
The ubiquitin-related modifier Urm1 can be covalently conjugated to lysine residues of other proteins, such as yeast Ahp1 and human MOCS3, through a mechanism involving the E1-like protein Uba4 (MOCS3 in humans). Similar to ubiquitination, urmylation requires a thioester intermediate and forms isopeptide bonds between Urm1 and its substrates. In addition, the urmylation process can be significantly enhanced by oxidative stress. Recent findings have demonstrated that Urm1 also acts as a sulfur… CONTINUE READING


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