The dual role of tumor necrosis factor (TNF) in cancer biology.

  title={The dual role of tumor necrosis factor (TNF) in cancer biology.},
  author={Loris Bertazza and Simone Mocellin},
  journal={Current medicinal chemistry},
  volume={17 29},
Tumor necrosis factor (TNF) is a cytokine with well known anticancer properties and is being utilized as anticancer agent for the treatment of patients with locally advanced solid tumors. However, TNF role in cancer biology is debated. In fact, in spite of the wealth of evidence supporting its antitumor activity, the cascade of molecular events underlying TNF-mediated tumor regression observed in vivo is still incompletely elucidated. Furthermore, some preclinical findings suggest that TNF may… CONTINUE READING


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