The dual role of p53: DNA protection and antioxidant.

  title={The dual role of p53: DNA protection and antioxidant.},
  author={Consuelo Borr{\'a}s and Mari Carmen Gomez-Cabrera and J. Vi{\~n}a},
  journal={Free radical research},
  volume={45 6},
The classical functions of p53 protein are those related to its role on DNA damage, cell growth arrest, senescence and apoptosis. For this reason it is called 'the guardian of the genome' and is considered one of the most important players in the development of cancer. However, more recently it has been show that p53 is not only involved in cancer, but also in ageing. p53 is stimulated by stress, which in turn results in the activation of a wide range of transcriptional targets. Low-intensity… CONTINUE READING