The dual role of fission yeast Tbc1/cofactor C orchestrates microtubule homeostasis in tubulin folding and acts as a GAP for GTPase Alp41/Arl2

@inproceedings{Mori2013TheDR,
  title={The dual role of fission yeast Tbc1/cofactor C orchestrates microtubule homeostasis in tubulin folding and acts as a GAP for GTPase Alp41/Arl2},
  author={Risa Mori and Takashi Toda},
  booktitle={Molecular biology of the cell},
  year={2013}
}
Supplying the appropriate amount of correctly folded α/β-tubulin heterodimers is critical for microtubule dynamics. Formation of assembly-competent heterodimers is remarkably elaborate at the molecular level, in which the α- and β-tubulins are separately processed in a chaperone-dependent manner. This sequential step is performed by the tubulin-folding cofactor pathway, comprising a specific set of regulatory proteins: cofactors A-E. We identified the fission yeast cofactor: the orthologue of… CONTINUE READING
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Analysis of a genome - wide set of gene deletions in the fission yeast Schizosaccharomyces pombe

  • DU Kim
  • Nat Biotechnol
  • 2010

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