The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A

@article{Ballabio2004TheDR,
  title={The dual role of endothelial differentiation-related factor-1 in the cytosol and nucleus: modulation by protein kinase A},
  author={Erica Ballabio and Massimo Mariotti and Lorenzo De Benedictis and Jeanette A. M. Maier},
  journal={Cellular and Molecular Life Sciences CMLS},
  year={2004},
  volume={61},
  pages={1069-1074}
}
Endothelial differentiation-related factor (EDF)-1 is involved in the repression of endothelial cell differentiation and is the first studied calmodulin (CaM)-binding protein in endothelial cells. Here we report that (i) EDF-1 is in vitro and in vivo phosphorylated by protein kinase A (PKA); (ii) EDF-1/CaM interaction is modulated by the phosphorylation of… CONTINUE READING