The dual role of a loop with low loop contact distance in folding and domain swapping.

@article{Linhananta2002TheDR,
  title={The dual role of a loop with low loop contact distance in folding and domain swapping.},
  author={Apichart Linhananta and Hongyi Zhou and Yaoqi Zhou},
  journal={Protein science : a publication of the Protein Society},
  year={2002},
  volume={11 7},
  pages={1695-701}
}
Alpha helices, beta strands, and loops are the basic building blocks of protein structure. The folding kinetics of alpha helices and beta strands have been investigated extensively. However, little is known about the formation of loops. Experimental studies show that for some proteins, the formation of a single loop is the rate-determining step for folding, whereas for others, a loop (or turn) can misfold to serve as the hinge loop region for domain-swapped species. Computer simulations of an… CONTINUE READING

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