The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking

@article{Khoo2017TheDO,
  title={The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking},
  author={Shaun Yon-Seng Khoo and Gavan P. McNally and Kelly J. Clemens},
  journal={PLoS ONE},
  year={2017},
  volume={12}
}
The orexin/hypocretin system is important for appetitive motivation towards multiple drugs of abuse, including nicotine. Both OX1 and OX2 receptors individually have been shown to influence nicotine self-administration and reinstatement. Due to the increasing clinical use of dual orexin receptor antagonists in the treatment of disorders such as insomnia, we examined whether a dual orexin receptor antagonist may also be effective in reducing nicotine seeking. We tested the effect of… 

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