The dual nature of HDL: Anti‐Inflammatory and pro‐Inflammatory

@article{NamiriKalantari2015TheDN,
  title={The dual nature of HDL: Anti‐Inflammatory and pro‐Inflammatory},
  author={Ryan Namiri-Kalantari and F. Gao and Arnab Chattopadhyay and Aerin Alese Wheeler and Kaveh Daniel Navab and Robin Farias-Eisner and Srinivasa T. Reddy},
  journal={BioFactors},
  year={2015},
  volume={41}
}
High density lipoprotein (HDL) has long been considered a protective factor against the development of coronary heart disease. Two important roles of HDL include reverse cholesterol transport (RCT) and the modulation of inflammation. The main protein component of HDL; apolipoprotein A‐I (apo A‐I) is primarily responsible for RCT. Apo A‐I can be damaged by oxidative mechanisms, which reduce the protein's ability to promote RCT. In disease states such as diabetes, associated with a chronic acute… Expand
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References

SHOWING 1-10 OF 54 REFERENCES
The double jeopardy of HDL
TLDR
Low‐density lipoprotein structure and function may be more important than HDL‐cholesterol levels in predicting risk for cardiovascular disease. Expand
HDL and cardiovascular disease: atherogenic and atheroprotective mechanisms
TLDR
Robust assays to evaluate the function of HDL are needed to supplement the measurement of HDL-cholesterol levels in the clinic, and small peptides that mimic some of the properties of apo A-I have been shown in preclinical models to improve HDL function and reduce atherosclerosis without altering HDL- cholesterol levels. Expand
HDL as a Biomarker, Potential Therapeutic Target, and Therapy
TLDR
The functions of HDL include reverse cholesterol transport and modulation of inflammation, which appear to have evolved as part of the innate immune system and may also lead to new therapeutic targets and therapies. Expand
Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures.
TLDR
Under basal conditions HDL serves an anti-inflammatory role but during APR displacement and/or exchange of proteins associated with HDL results in a pro-inflammatory molecule. Expand
Effect of a short-term diet and exercise intervention on inflammatory/anti-inflammatory properties of HDL in overweight/obese men with cardiovascular risk factors.
TLDR
The data indicate that intensive lifestyle modification improves the function of HDL even in the face of reduced levels, suggesting increased turnover of proinflammatory HDL. Expand
Reconstituted high-density lipoprotein increases plasma high-density lipoprotein anti-inflammatory properties and cholesterol efflux capacity in patients with type 2 diabetes.
OBJECTIVES Our aim was to investigate the effects of reconstituted high-density lipoprotein (rHDL) infusions on plasma high-density lipoprotein (HDL) anti-inflammatory properties and ex vivoExpand
Inflammatory/Antiinflammatory Properties of High-Density Lipoprotein Distinguish Patients From Control Subjects Better Than High-Density Lipoprotein Cholesterol Levels and Are Favorably Affected by Simvastatin Treatment
TLDR
The inflammatory/antiinflammatory properties of HDL distinguished patients from control subjects better than HDL cholesterol and were improved with simvastatin. Expand
HDL-inflammatory index correlates with poor outcome in hemodialysis patients.
TLDR
An important role of inflammatory HDL in patients with CKD leading to poor outcome is suggested, with patients with a higher HDL proinflammatory index having a higher 30-month adjusted hazard ratio for death than those whose HDL were seen to be anti-inflammatory. Expand
Can dysfunctional HDL explain high coronary artery disease risk in South Asians?
TLDR
The measurement of HDL level as well as functionality plays an important role in CAD risk assessment, and those SAIs with dysfunctional HDL and without known CAD can be a high risk group requiring treatment with lipid lowering drugs to reduce future risk of CAD. Expand
Apolipoprotein A-I mimetic peptides
TLDR
The apoA-I mimetic peptide 4F increased the formation of pre-β high-density lipoprotein, increased cholesterol efflux, and reduced lipop protein oxidation in vitro; it increased antioxidants and vascular repair in type 1 diabetic rats; it improved high- density lipop Protein inflammatory properties in humans with coronary heart disease. Expand
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