The dual face of heparin in severe infection.

Abstract

In this issue of Blood, Wildhagen et al demonstrate that nonanticoagulant heparin effectively blocks histone-mediated cytotoxicity and improves survival in animal models of severe infection and inflammation. Activation of coagulation and inflammation are important and intertwined mechanisms in the pathogenesis of serious infection and sepsis… (More)
DOI: 10.1182/blood-2013-12-541250

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