The dsRNA binding site of human Toll-like receptor 3.

@article{Bell2006TheDB,
  title={The dsRNA binding site of human Toll-like receptor 3.},
  author={Jessica K. Bell and Janine Askins and Pamela R Hall and David Rhodri Davies and David M. Segal},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2006},
  volume={103 23},
  pages={8792-7}
}
Pathogen recognition by Toll-like receptors (TLRs) initiates innate immune responses that are essential for inhibiting pathogen dissemination and for the development of acquired immunity. The TLRs recognize pathogens with their N-terminal ectodomains (ECD), but the molecular basis for this recognition is not known. Recently we reported the x-ray structure for unliganded TLR3-ECD; however, it has proven difficult to obtain a crystal structure of TLR3 with its ligand, dsRNA. We have now located… CONTINUE READING
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